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Volume 27: Compounds with Two Carbon¾Heteroatom Bonds
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Introduction by Prof. Albert Padwa (Volume Editor): |
| This volume of Science of Synthesis covers compounds containing two carbon–heteroatom
bonds. These heteroatom analogues of aldehydes and ketones are extensively used
for the synthesis of complex organic molecules and thus have been studied for a very long
period of time. The book consists of 23 chapters that discuss the different functional
groups of interest. The pattern in which each chapter is covered follows a regular plan
ordered according to Science of Synthesis guidelines. First, there is a general equation
illustrating various approaches toward the synthesis of the particular functional group
being reviewed. Each reaction is discussed with emphasis on its particular value and limitations.
A limited amount of background and theory is often included, not only to account
for the path that the reaction takes, but also for its limitations and any byproducts
formed. Finally, examples are given, many in sufficient detail to permit preparation in
the laboratory and others to illustrate minor variations not necessarily presented in the
discussion. Treatment is both selective and critical, the most important fact desired is the
preferred methods of synthesis of a particular functional group.
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| Emphasis is placed on providing recent references, since the original synthetic method
may have been improved. Some references are included as benchmark papers and
others for their historical interest. Many review references are also included. With the explosive
growth of synthetic organic chemistry still continuing, it is impossible to avoid
omissions. Each author is an authority in the field and references are provided through
2003. The best synthetic methods available as well as additional information on the scope
and limitations of each functional group are nicely summarized by this group of experts.
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