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Volume 13: Five-Membered Hetarenes with Three or More Heteroatoms |
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Introduction by Dr. R. C. Storr
and Dr. T. L. Gilchrist (Volume Editors): |
| This volume of Science of Synthesis includes a wide variety of five-membered heterarenes
containing three or more heteroatoms in the ring. The types and arrangements
of heteroatoms in these structures are great. Many of the structures that contain combinations
of carbon with nitrogen, oxygen, and sulfur are well-known to most organic
chemists, but others that contain elements such as phosphorus, arsenic, antimony, and
selenium among the heteroatoms are much less familiar. Most of the known ring systems
that include combinations of these heteroatoms are included. |
| The main purpose of the volume, like others in the Science of Synthesis series, is to
describe reliable methods of synthesis for structures in each product class. Other aspects
of the chemistry of the ring systems are covered only briefly unless they are relevant to
methods for preparation of compounds in the class. Substitution reactions that lead to
new derivatives of the ring systems are included since they represent important methods
of preparation in most of the product classes. The principal methods of synthesis are,
however, those that involve construction of the ring systems from acyclic starting materials.
A wide range of building blocks can potentially be used because of the presence of
several heteroatoms in the target ring systems and this leads to a choice of several different
methods of construction for most of the ring systems. |
| The commercial importance of several of the hetarenes covered in this volume can
hardly be overestimated since they are key components of some of the most common
pharmaceuticals, agrochemicals, and dyestuffs and have many other applications. We
may not be the only chemists who were initially unfamiliar with the chemistry and uses
of some of the less common ring systems, or even of their existence: the (inorganic) pentaphospide
anion (Product Class 13.26) and its use as a ligand is a case in point. We are grateful
to all the members of the team of experts who have contributed to the volume and
have enabled us to include such a variety of chemistry. |
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