A new update to Pharmaceutical Substances was released on January 25, 2010. The new release features 20 new active pharmaceutical ingredients and 3 updated syntheses:

Pharmaceutical Substances is compatible with IE and Mozilla 5.0 (e.g., Firefox) on PC's and Safari 2.0 (on MAC's running OS X).

With version 3.3, Pharmaceutical Substances supports ChemDraw 9.0.1 and 10.0.

You can download a detailed user manual for the built-in structure editor here.