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Enantioselective Ring Opening of Epoxides by Fluoride Anion
Stereocontrolled incorporation of fluorine into organic molecules remains a challenging endeavor, despite remarkable recent progress in the field. The use of fluoride anion in catalytic C–F bond-forming reactions is particularly attractive, not only for economic and environmental reasons, but also because it could have important applications in emerging fields, such as positron emission tomography. Recently, the group of Professor Abigail G. Doyle from Princeton University (USA) reported an interesting methodology for the ring opening of meso-epoxides by fluoride anion.
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